Bromine

RTECS #

EF9100000

CAS #

7726-95-6
See: NMAM or OSHA Methods

Updated

October 2014

Molecular Weight

159.82

Molecular Formula

Br₂

Synonyms

Brom (German)
Brome (French)
Bromine (ACGIH:OSHA)
Bromo (Italian)
Broom (Dutch)
Dibromine

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 1200 mg/m³		VCVN5* -,389,1989
inhalation/cat	Lowest published lethal concentration: 150 mg/m³/7H	Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea	VCVN5* -,389,1989
inhalation/guinea pig	Lowest published lethal concentration: 150 mg/m³/7H	Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea	VCVN5* -,389,1989
inhalation/guinea pig	Lowest published lethal concentration: 1200 mg/m³		VCVN5* -,389,1989
inhalation/human	Lowest published lethal concentration: 1000 ppm		34ZIAG -,645,1969
inhalation/human	lowest published toxic concentration: 13 mg/m³	Lung, Thorax, or Respiration: Cough	VCVN5* -,390,1989
inhalation/human	lowest published toxic concentration: 11 mg/m³	Lung, Thorax, or Respiration: Respiratory depression	VCVN5* -,390,1989
inhalation/human	Lowest published lethal concentration: 220 mg/m³		VCVN5* -,390,1989
inhalation/mammal (species unspecified)	lowest published toxic concentration: 50 mg/m³	Cardiac: Other changes Endocrine: Other changes	VCVN5* -,389,1989
inhalation/mammal (species unspecified)	lowest published toxic concentration: 100 mg/m³	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VCVN5* -,389,1989
inhalation/mouse	lethal concentration (50 percent kill): 2900 mg/m³		VCVN5* -,389,1989
inhalation/mouse	lethal concentration (50 percent kill): 750 ppm/9M		AIHAAP 39,129,1978
inhalation/rabbit	Lowest published lethal concentration: 180 ppm/6.5H		HBTXAC 1,324,1955
inhalation/rabbit	Lowest published lethal concentration: 1200 mg/m³		VCVN5* -,389,1989
inhalation/rabbit	Lowest published lethal concentration: 150 mg/m³/7H	Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea	VCVN5* -,389,1989
inhalation/rat	lethal concentration (50 percent kill): 2700 mg/m³	Lung, Thorax, or Respiration: Other changes	GTPZAB 20(3),36,1976
inhalation/rat	lethal concentration (50 percent kill): 2700 mg/m³		VCVN5* -,389,1989
inhalation/rat	lowest published toxic concentration: 10 mg/m³/4H	Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Respiratory depression	VCVN5* -,389,1989
inhalation/rat	lowest published toxic concentration: 10 mg/m³/4H	Behavioral: Alteration of classical conditioning	TPKVAL 14,63,1975
inhalation/rat	lowest published toxic concentration: 500 mg/m³/4H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TPKVAL 14,63,1975
inhalation/rat	lowest published toxic concentration: 100 mg/m³/4H	Lung, Thorax, or Respiration: Other changes	TPKVAL 14,63,1975
inhalation/rat	lowest published toxic concentration: 200 mg/m³/4H	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TPKVAL 14,63,1975
oral/guinea pig	lethal dose (50 percent kill): 5500 mg/kg		VCVN5* -,389,1989
oral/human	lowest published lethal dose: 14 mg/kg		34ZIAG -,645,1969
oral/mammal (species unspecified)	lethal dose (50 percent kill): 440 mg/kg		GISAAA 39(4),86,1974
oral/mouse	lethal dose (50 percent kill): 3100 mg/kg		VCVN5* -,389,1989
oral/rabbit	lethal dose (50 percent kill): 2500 mg/kg		VCVN5* -,389,1989
oral/rat	lethal dose (50 percent kill): 1700 mg/kg		VCVN5* -,389,1989
skin/pig	lowest published toxic dose: 0.06 mL/kg	Skin: After systemic exposure: Dermatitis, irritative Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOLED5 182,69,2008

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	lowest published toxic concentration: 12.4 mg/m³/24H/17W- continuous	Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVN5* -,390,1989
inhalation/rabbit	lowest published toxic concentration: 1.4 mg/m³/24H/17W- continuous	Olfaction: Other olfaction effects	VCVN5* -,390,1989
inhalation/rat	lowest published toxic concentration: 1.4 mg/m³/24H/17W- continuous	Olfaction: Other olfaction effects	VCVN5* -,390,1989
inhalation/rat	lowest published toxic concentration: 1400 µg/m³/17W- intermittent	Lung, Thorax, or Respiration: Respiratory depression Endocrine: Evidence of thyroid hypofunction Endocrine: Changes in thyroid weight	GTPZAB 20(3),36,1976
inhalation/rat	lowest published toxic concentration: 12.4 mg/m³/24H/17W- continuous	Cardiac: Other changes Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVN5* -,390,1989
oral/rat	lowest published toxic dose: 3094 mg/kg/13W- intermittent	Endocrine: Hyperglycemia Skin and Appendages: Other: Hair Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVN5* -,390,1989
unreported route/rat	lowest published toxic dose: 3375 mg/kg/15D- intermittent	Endocrine: Estrogenic	VCVN5* -,390,1989

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm;short term exposure limit 0.2 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		KOTTAM 11,1300,1975
TOXICOLOGY REVIEW		FOREAE 7,313,1942
TOXICOLOGY REVIEW		CLCHAU 19,361,1973
TOXICOLOGY REVIEW		ENTOX* -,342,2005
TOXICOLOGY REVIEW		HUTOX* -,661,1996
TOXICOLOGY REVIEW		TOLED5 198,297,2010

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,298,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 ppm (0.7 mg/m³)	DTLVS* 3,27,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.66 mg/m³), short term exposure limit 0.3 ppm (2 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.7 mg/m³);KZW 0.1 ppm (0.7 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.67 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 0.2 ppm (1.3 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.7 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 0.7 mg/m³ (0.1 ppm), FEB2006
Occupational Exposure Limit-FINLAND	short term exposure limit 0.1 ppm (0.66 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 0.1 ppm (0.7 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 0.7 mg/m³, short term exposure limit 0.7 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.7 mg/m³), NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.1 ppm (0.7 mg/m³), short term exposure limit 0.3 ppm (2 mg/m³), JAN1993
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.1 ppm (0.65 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.7 mg/m³), short term exposure limit 0.3 ppm (2 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 ppm (0.7 mg/m³);short term exposure limit 0.3 ppm (2 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.66 mg/m³); short term exposure limit 0.3 ppm (2 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.1 ppm (0.65 mg/m³); short term exposure limit 0.2 ppm (1.3 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.7 mg/m³, MAC(short term exposure limit) 2 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.5 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.7 mg/m³);short term exposure limit 0.3 ppm (2 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (0.7 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.7 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.1 ppm (0.66 mg/m³);short term exposure limit 0.2 ppm (1.3 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 ppm (0.7 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 ppm (0.7 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 ppm (0.7 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 ppm (0.7 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMINE-air	10H time-weighted average 0.1 ppm;short term exposure limit 0.3 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 13100; Number of Industries 40; Total Number of Facilities 1679; Number of Occupations 55; Total Number of Employees Exposed 62214; Total Number of Female Employees Exposed 10780
National Occupational Hazard Survey 1974	Hazard Code 13100; Number of Industries 17; Total Number of Facilities 583; Number of Occupations 16; Total Number of Employees Exposed 23977

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
OSHA ANALYTICAL METHOD #ID-108

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health