NIOSH logo and tagline

Methacrylic acid, methyl ester

RTECS #
OZ5075000
CAS #
80-62-6
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
100.13
Molecular Formula
C5H8O2
Synonyms
2-(Methoxycarbonyl)-1-propene
2-Methyl-2-propenoic acid methyl ester
2-Propenoic acid, 2-methyl-, methyl ester
Acrylic acid, 2-methyl-, methyl ester
Metakrylan metylu (Polish)
Methacrylate de methyle (French)
Methacrylsaeuremethyl ester (German)
Methyl 2-methyl-2-propenoate
Methyl alpha-methylacrylate
Methyl methacrylate
Methyl methacrylate (ACGIH:OSHA)
Methyl methacrylate monomer
Methyl methylacrylate
Methyl-2-methyl-2-propenoate
Methyl-2-methylpropenoate
Methylester kyseliny methakrylove (Czech)
Methylmethacrylaat (Dutch)
Methyl-methacrylat (German)
Metil metacrilato (Italian)
MME
NCI-C50680
Pegalan
RCRA waste number U162

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 150 mgINMEAF 14,292,1945
skin /rabbit 10 gm open irritation testJIHTAB 23,343,1941
skin /woman 2%/48HCODEDG 57,21,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat4 mg/m3/16WBZARAZ 27(6),102,1974
Cytogenetic Analysislymphocyte/mouse2799 mg/LEMMUEG 11,49,1988
Cytogenetic Analysislymphocyte/mouse2202 mg/LMUREAV 222,191,1989
Cytogenetic Analysisovary/hamster1600 mg/LNTPTR* NTP-TR-314,1986
micronucleus testlymphocyte/mouse2202 mg/LMUREAV 222,191,1989
mutation in mammalian somatic cellslymphocyte/mouse704 mg/LNTPTR* NTP-TR-314,1986
mutation in microorganismslymphocyte/mouse500 mg/L (+enzymatic activation step)ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms/Salmonella typhimurium34 mmol/L (-enzymatic activation step)JBJSA3 61A,1203,1979
sister chromatid exchangeovary/hamster1500 mg/LNTPTR* NTP-TR-314,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/woman 10 mg/m3 (9Y pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on newborn: Delayed effects
GISAAA 62(4),19,1997
inhalation/rat 109 gm/m3/17M (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 50,451,1979
inhalation/rat 109 gm/m3/54M (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
TXAPA9 50,451,1979
inhalation/rat 54 mg/m3/24H (8W prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disordersGTPZAB 21(2),49,1977
inhalation/rat 4480 mg/m3/2H (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOLED5 31(Suppl),80,1986
inhalation/mouse 116 ppm/6H (4-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0555600
inhalation/rat 500 mg/m3 (122D prior to copulation)Reproductive: Other developmental abnormalitiesPREND* 37,51,1991
inhalation/rat 500 mg/m3 (119D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
PROEAS 37,51,1991
inhalation/rat 500 mg/m3 (98D prior to copulation/21D pregnant)Reproductive: Other developmental abnormalitiesPROEAS 37,51,1991
intraperitoneal/rat 405 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
JDREAF 51,1632,1972
intraperitoneal/rat 801 mg/kg (5-15D pregnant)Reproductive: Other developmental abnormalitiesJDREAF 51,1632,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 1620 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CORTBR 88,223,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 176 gm/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 63 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 157 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 61 gm/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 1.8 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 2.7 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lymphocyte Inhibitor Concentration (30 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (50 percent kill): 157 mg/L/45HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,901,2015
In Vitro/Human, skin Inhibitor Concentration Low: 10 µmol/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 283,147,2015
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 400.5 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/Human, skin Inhibitor Concentration Low: 400.5 mg/L/4HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,314,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.7 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.6 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/mraInhibitor Concentration (25 percent kill): 5000 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 216,65,2013
In Vitro/mraInhibitor Concentration Low: 50 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTOLED5 216,65,2013
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): >501.2 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): >501.2 mmol/L/1HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 123 mmol/L/1HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIVIEQ 32,347,2016
inhalation/Dog Lowest published lethal concentration: 41200 mg/m3/3HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
inhalation/guinea pig Lowest published lethal concentration: 19000 mg/m3/5HBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
inhalation/human lowest published toxic concentration: 125 ppmBehavioral: Sleep

Behavioral: Excitement

Behavioral: Anorexia (human)
GISAAA 19(10),25,1954
inhalation/human lowest published toxic concentration: 60 mg/m3Behavioral: Sleep

Behavioral: Excitement

Vascular: BP lowering not characterized in autonomic section
GTPZAB 1,56,1957
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 20 gm/m3GISAAA 51(5),61,1986
inhalation/mouse lethal concentration (50 percent kill): 18500 mg/m3/2HGTPZAB 20(6),5,1976
inhalation/rabbit Lowest published lethal concentration: 17500 mg/m3/4.5HBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
inhalation/rat lethal concentration (50 percent kill): 78000 mg/m3/4HGTPZAB 20(6),5,1976
inhalation/rat lowest published toxic concentration: 400 ppm/4HOlfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects
TOXID9 60,150,2001
intraperitoneal/guinea pig lethal dose (50 percent kill): 1890 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945
intraperitoneal/mouse lethal dose (50 percent kill): 945 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945
intraperitoneal/rat lethal dose (50 percent kill): 1328 mg/kgJDREAF 51,1632,1972
intravenous/Dog lowest published lethal dose: 120 µL/kgJPMSAE 63,376,1974
oral/Dog lethal dose (50 percent kill): 4725 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
oral/guinea pig lethal dose (50 percent kill): 5954 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
oral/mouse lethal dose (50 percent kill): 3625 mg/kgGISAAA 41(4),6,1976
oral/rabbit lethal dose (50 percent kill): 8700 mg/kgGISAAA 41(4),6,1976
oral/rat lethal dose (50 percent kill): 7872 mg/kgBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
skin/rabbit lethal dose (50 percent kill): >5 gm/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0544282
subcutaneous/cat lowest published lethal dose: 7 mL/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
NTIS** OTS0520933
subcutaneous/Dog lethal dose (50 percent kill): 4252 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945
subcutaneous/guinea pig lethal dose (50 percent kill): 5954 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945
subcutaneous/mouse lethal dose (50 percent kill): 5954 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945
subcutaneous/rabbit lowest published lethal dose: 14 mL/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0520933
subcutaneous/rat lethal dose (50 percent kill): 7088 mg/kgBehavioral: Somnolence (general depressed activity)INMEAF 14,292,1945

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 15 gm/m3/7H/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0520933
inhalation/Dog lowest published toxic concentration: 47 gm/m3/90M/15D- intermittentLiver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INMEAF 14,292,1945
inhalation/guinea pig lowest published toxic concentration: 65 gm/m3/3H/3D- intermittentLiver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INMEAF 14,292,1945
inhalation/hamster lowest published toxic concentration: 400 ppm/6H/78W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0521056
inhalation/mouse lowest published toxic concentration: 41 gm/m3/90M/15D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldINMEAF 14,292,1945
inhalation/mouse lowest published toxic concentration: 5000 ppm/6H/14W- intermittentOlfaction: Other olfaction effects

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-314,1986
inhalation/mouse lowest published toxic concentration: 500 ppm/6H/2Y- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
TXCYAC 52,237,1988
inhalation/mouse lowest published toxic concentration: 30900 mg/kg/103W- intermittentReproductive: Tumorigenic effects: Uterine tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB87-146742/AS
inhalation/rabbit lowest published toxic concentration: 15 gm/m3/7H/5D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
NTIS** OTS0520933
inhalation/rat lowest published toxic concentration: 50 mg/m3/4H/30D- intermittentEndocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight
PREND* 37,51,1991
inhalation/rat lowest published toxic concentration: 500 mg/m3/4H/122D- intermittentEndocrine: Other changesPREND* 37,51,1991
inhalation/rat lowest published toxic concentration: 116 ppm/8H/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ENVRAL 11,66,1976
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/14W- intermittentBrain and Coverings: Changes in circulation

Olfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-314,1986
inhalation/rat lowest published toxic concentration: 34500 mg/m3/16W- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
GISAAA 45(10),74,1980
inhalation/rat lowest published toxic concentration: 1 mg/m3/24H/60D- continuousBehavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
GISAAA 27(11),3,1962
inhalation/rat lowest published toxic concentration: 115 mg/m3/3H/17W- intermittentCardiac: EKG changes not diagnostic of above

Blood: Other changes
GISAAA 45(1),34,1980
inhalation/rat lowest published toxic concentration: 500 ppm/6H/2Y- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
TXCYAC 52,237,1988
inhalation/rat lowest published toxic concentration: 50 mg/m3/4H/4W- intermittentEndocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight
PROEAS 37,51,1991
inhalation/rat lowest published toxic concentration: 50 mg/m3/4H/17W- intermittentBrain and Coverings: Other degenerative changesPROEAS 37,51,1991
inhalation/rat lowest published toxic concentration: 15450 mg/kg/103W- intermittentBrain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB87-146742/AS
intraperitoneal/mouse lowest published toxic dose: 19665 mL/kg/15W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJBMRBG 8,11,1974
oral/Dog lowest published toxic dose: 1825 mg/kg/2Y- continuousEndocrine: Changes in spleen weightTXAPA9 6,29,1964
oral/rabbit lowest published toxic dose: 97500 µg/kg/39W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 41(4),6,1976
oral/rat lowest published toxic dose: 10500 mg/kg/21D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport
INHEAO 27,121,1989
oral/rat lowest published toxic dose: 17896 mg/kg/35W- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
AMPMAR 32,653,1971

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppm (sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 19,187,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,187,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,445,1994
International Agency for Research on Cancer (IARC)Cancer Review:Animal LACK CARCINOGENICITYIMEMDT 60,445,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,445,1994
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWCMTVAS 10(3),49,1973
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWTOLED5 138,9,2003
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWIJTOFN 24,53,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWRTOPDW 54,294,2009
TOXICOLOGY REVIEWRTOPDW 55,43,2009
TOXICOLOGY REVIEWRTOPDW 56,54,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (410 mg/m3)DTLVS* 3,168,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (208 mg/m3), short term exposure limit 100 ppm (416 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (210 mg/m3);KZW 100 ppm (420 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (416 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (102 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (42 mg/m3), short term exposure limit 50 ppm (210 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (410 mg/m3), VLE 200 ppm (820 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 50 ppm (210 mg/m3), skin, sen, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 210 mg/m3, short term exposure limit 210 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (102 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 2 ppm, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (410 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (410 mg/m3);short term exposure limit 125 ppm (510 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (208 mg/m3); short term exposure limit 100 ppm (416 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (205 mg/m3); short term exposure limit 100 ppm (410 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 400 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (200 mg/m3);short term exposure limit 150 ppm (600 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (210 mg/m3), KZG-week 100 ppm (420 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (410 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (208 mg/m3);short term exposure limit 100 ppm (416 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (410 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (410 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (410 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (410 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL METHACRYLATE-air10H time-weighted average 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 47700; Number of Industries 76; Total Number of Facilities 6757; Number of Occupations 80; Total Number of Employees Exposed 170079; Total Number of Female Employees Exposed 59519
National Occupational Hazard Survey 1974Hazard Code 47700; Number of Industries 89; Total Number of Facilities 11522; Number of Occupations 73; Total Number of Employees Exposed 89435

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Methyl methacrylate, 2537
On EPA IRIS database
OSHA ANALYTICAL METHOD #94
Page last reviewed: November 16, 2018