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1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-,endo,endo-

RTECS #
IO1575000
CAS #
72-20-8
See: NMAM or OSHA Methods
Updated
December 2016
Molecular Weight
380.90
Molecular Formula
C12H8Cl6O
Synonyms
Compound 269
EN 57
Endrex
Endricol
Endrin
Endrin (ACGIH:OSHA)
Endrine (French)
ENT 17,251
Experimental insecticide 269
Hexachloroepoxyoctahydro-endo,endo-dimethanonaphthalene
Hexadrin
Latka 269 (Czech)
Mendrin
NCI-C00157
Oktanex
OMS 197
RCRA waste number P051
SD 3419
Stardrin
Stardrin 20

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisparenteral/rat1 mg/kgBECTA6 9,65,1973
sister chromatid exchangemultiple/other fish54 pmol/LMUREAV 118,61,1983
sperm morphologyparenteral/rat10 mg/kg/10D-continuousAPTOA6 31,1,1972

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 10 mg/kg (10D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)APTOA6 31,1,1972
oral/mouse 10 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JTEHD6 10,541,1982
oral/mouse 2500 µg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 9,11,1974
oral/mouse 2320 µg/kg (4D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
OYYAA2 6,673,1972
oral/mouse 7 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 5,3,1985
oral/mouse 16500 µg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTXCYAC 21,141,1981
oral/hamster 15 mg/kg (5-14D pregnant)Reproductive: Effects on newborn: BehavioralTXCYAC 21,187,1981
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 9,11,1974
oral/hamster 7500 µg/kg (5-14D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)TXAPA9 48,A200,1979
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 48,A201,1979
oral/rat 2320 µg/kg (4D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
OYYAA2 6,673,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/mouse lethal dose (50 percent kill): 400 µg/kgBehavioral: Convulsions or effect on seizure thresholdTOLED5 60,289,1992
intraperitoneal/mouse lethal dose (50 percent kill): 5 mg/kgTOLED5 60,289,1992
intravenous/mouse lethal dose (50 percent kill): 2300 µg/kgTXAPA9 23,408,1972
intravenous/pigeon lethal dose (50 percent kill): 1500 µg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,75,1966
oral/cat lowest published lethal dose: 5 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
oral/chicken lowest published lethal dose: 2 mg/kgBehavioral: Ataxia

Behavioral: Irritability
CNVJA9 11,74,1970
oral/Dog lowest published lethal dose: 20 mg/kgJFSCAS 29,331,1989
oral/duck lethal dose (50 percent kill): 5330 µg/kgTXAPA9 22,556,1972
oral/guinea pig lethal dose (50 percent kill): 16 mg/kgPCOC** -,475,1966
oral/hamster lethal dose (50 percent kill): 10 mg/kgTJADAB 9,11,1974
oral/man lowest published lethal dose: 171 mg/kgBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Thrombocytopenia
HUTODJ 4,241,1985
oral/monkey lethal dose (50 percent kill): 3 mg/kgPCOC** -,475,1966
oral/mouse lowest published toxic dose: 137 µg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
oral/mouse lethal dose (50 percent kill): 1370 µg/kgENTOX* -,176,2005
oral/pigeon lethal dose (50 percent kill): 5600 µg/kgTXAPA9 21,315,1972
oral/quail lethal dose (50 percent kill): 4210 µg/kgASTTA8 (680),157,1979
oral/rabbit lethal dose (50 percent kill): 7 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
oral/rat lethal dose (50 percent kill): 3 mg/kgWRPCA2 9,119,1970
oral/wild bird lethal dose (50 percent kill): 1780 µg/kgASTTA8 (680),157,1979
oral/woman lowest published lethal dose: 234 mg/kgBehavioral: Headache

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
NEZAAQ 22,254,1967
skin/cat lowest published lethal dose: 75 mg/kgBehavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting
CVETAA 2,71,1958
skin/rabbit lethal dose (50 percent kill): 60 mg/kgSPEADM 78-1,13,1978
skin/rat lethal dose (50 percent kill): 12 mg/kgSPEADM 78-1,13,1978
unreported route/rabbit lethal dose (50 percent kill): 7 mg/kg30ZDA9 -,64,1971
unreported route/rat lethal dose (50 percent kill): 17 mg/kg30ZDA9 -,64,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 360 ppb/7H/22W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
inhalation/rabbit lowest published toxic concentration: 360 ppb/7H/24W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
oral/Dog lowest published toxic dose: 12150 µg/kg/81W- intermittentCardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JAFCAU 3,842,1955
oral/rabbit lowest published toxic dose: 50 mg/kg/72D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
oral/rat lowest published toxic dose: 1975 mg/kg/79D- intermittentEye: Hemorrhage

Behavioral: Excitement

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 14,556,1969
oral/rat lowest published toxic dose: 219 mg/kg/2Y- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes
JAFCAU 3,842,1955
oral/rat lowest published toxic dose: 6720 mg/kg/16W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAFCAU 4,696,1956
skin/rabbit lowest published toxic dose: 1400 mg/kg/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 5,157,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 5,157,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWENVRAL 7,243,1974
TOXICOLOGY REVIEWBECTA6 15,283,1976
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEW26UZAB 6,149,1968/1970
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,176,2005
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,180,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,98,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 1 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg/m3. inhal., skin, 2011
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.8 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDRIN-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-12,1979
NIOSH Analytical Method, 1994: Endrin, 5519
On EPA IRIS database
Page last reviewed: November 16, 2018