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1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro-

RTECS #
GY1225000
CAS #
77-47-4
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
272.75
Molecular Formula
C5Cl6
Synonyms
1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
C-56
Graphlox
Hexachlorcyklopentadien (Czech)
Hexachloro-1,3-cyclopentadiene
Hexachlorocyclopentadiene
Hexachlorocyclopentadiene (ACGIH)
HRS 1655
NCI-C55607
Perchlorocyclopentadiene
RCRA waste number U130

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,149,1986
eye /rabbit 100 mg/5M severeVELPB* #50101-2,1976
skin /guinea pig 20 mg mildAMIHAB 11,459,1955
skin /monkey 10 mg severeAMIHAB 11,459,1955
skin /rabbit 500 mg/4H severeVELPB* #50101-2,1976
skin /rabbit 500 µL/24H severeNTIS** OTS0537036

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/hamster27.5 µmol/LMUREAV 608,28,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 975 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 53,497,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 84 mg/m3/7HVCVGH* -,551,1990
inhalation/Dog Lowest published lethal concentration: 840 mg/m3/30MVCVGH* -,551,1990
inhalation/guinea pig Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/guinea pig Lowest published lethal concentration: 3200 ppb/7HAMIHAB 11,459,1955
inhalation/mouse Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/mouse Lowest published lethal concentration: 1500 ppb/7HTXAPA9 53,497,1980
inhalation/rabbit Lowest published lethal concentration: 1500 ppb/7HTXAPA9 53,497,1980
inhalation/rabbit Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/rat lethal concentration (50 percent kill): 23 mg/m3/2HVCVGH* -,551,1990
inhalation/rat Lowest published lethal concentration: 139 mg/m3/3HVCVGH* -,551,1990
inhalation/rat lethal concentration (50 percent kill): 1600 ppb/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
JTEHD6 9,743,1982
oral/mouse lethal dose (50 percent kill): 505 mg/kgJAFCAU 23,967,1975
oral/rabbit lowest published lethal dose: 420 mg/kgPCOC** -,586,1966
oral/rabbit lethal dose (50 percent kill): 620 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
ENTOX* -,517,2005
oral/rat lethal dose (50 percent kill): 420 mg/kgLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
ENTOX* -,517,2005
oral/rat lethal dose (50 percent kill): 200 mg/kgVCVGH* -,552,1990
skin/rabbit lowest published lethal dose: 300 mg/kgVCVGH* -,552,1990
skin/rabbit lethal dose (50 percent kill): 430 mg/kg34ZIAG -,308,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 11,459,1955
inhalation/mouse lowest published toxic concentration: 150 ppb/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,57,1986
inhalation/mouse lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,459,1955
inhalation/rabbit lowest published toxic concentration: 340 ppb/7H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,459,1955
inhalation/rat lowest published toxic concentration: 100 ppb/6H/30W- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0539137
inhalation/rat lowest published toxic concentration: 500 ppb/6H/2W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 9,743,1982
inhalation/rat lowest published toxic concentration: 400 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight
NTPTR* NTP-TR-437,1994
oral/mouse lowest published toxic dose: 2470 mg/kg/13W- intermittentGastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
JJATDK 4,75,1984
oral/rat lowest published toxic dose: 2470 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJATDK 4,75,1984

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,517,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOLED5 204,148,2011
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUTAEX 32,491,2017
TOXICOLOGY REVIEWRTOPDW 54,294,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 ppm (0.11 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 ppm (0.11 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.1 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 ppm (0.11 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.01 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 ppm (0.1 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.01 ppm (0.1 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.01 ppm (0.1 mg/m3);short term exposure limit 0.03 ppm (0.3 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 ppm (0.11 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,01 ppm (0,11 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.01 ppm (0.1 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROCYCLOPENTADIENE-air10H time-weighted average 0.01 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code T0175; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 14; Total Number of Employees Exposed 1427

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166670)
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518
NTP Carcinogenesis studies (inhalation);no evidence:rat NTPTR* NTP-TR-437,1994
On EPA IRIS database
Page last reviewed: November 16, 2018