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Carbamic acid, methyl-, o-isopropoxyphenyl ester

RTECS #
FC3150000
CAS #
114-26-1
See: NMAM or OSHA Methods
Updated
December 2017
Molecular Weight
209.27
Molecular Formula
C11H15NO3
Synonyms
2(1-Methylethoxy)phenol methyl carbamate
2-(1-Methylethoxy)phenol methylcarbamate
2-Isopropoxyphenyl N-methylcarbamate
2-Isopropoxyphenyl-N-methylcarbamat (German)
2-Isopropoxyphenyl-N-methylcarbamate
Arprocarb
BAY 39007
BAY 5122
Bayer 39007
Bayer B 5122
Baygon
Baygon (OSHA)
Blattanex
Blattosep
Carbamic acid, methyl-, 2-(1-methylethoxy)phenyl ester
Chemagro 9010
ENT 25,671
Invisi-Gard
n-2-(1-Methylethoxy)phenyl methyl-carbamate
o-IMPC
o-Isopropoxyphenyl N-methylcarbamate
OMS-33
PHC (carbamate)
PHC 7
Phenol, o-isopropoxy-, methylcarbamate
Propoksuru (Polish)
Propoxur
Propoxur (ACGIH)
Propoxylor
Sendran
Suncide
Tendex
Tugon fliegenkugel
Unden (pesticide)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster0.05 mg/L/1HFCTOD7 45,928,2007
Cytogenetic Analysisovary/hamster0.04 mg/L/2HFCTOD7 45,928,2007
Cytogenetic Analysisintraperitoneal/hamster250 mg/kgARTODN 58,152,1986
DNA Damageother cell types/other fish75 mg/L/24HTIVIEQ 28,340,2014
DNA Damageoral/rabbit534.36 mg/kg/1Y- intermittentTXCYAC 307,109,2013
Dominant Lethal Testoral/mouse125 mg/kg/5D-continuousGISAAA 44(7),75,1979
micronucleus testlymphocyte/human50 mg/LMUREAV 232,45,1990
mutation in microorganisms/Salmonella typhimurium250 ng/plate (+enzymatic activation step)RPZHAW 30,81,1979
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
sister chromatid exchangelymphocyte/human50 mg/LMUREAV 232,45,1990
sister chromatid exchangelung/hamster200 mg/LCRNGDP 19,623,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1600 mg/kg (6-22D preg/15D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects
BECTA6 20,624,1978
oral/rat 650 mg/kg (7-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJPFCD2 20,373,1985
oral/mouse 600 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JPFCD2 20,373,1985
oral/mouse 50 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJPFCD2 20,373,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/nzxInhibitor Concentration Low: 75 mg/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 28,340,2014
In Vitro/nzxInhibitor Concentration (50 percent kill): 89.96 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,340,2014
In Vitro/nzxInhibitor Concentration (50 percent kill): 103.4 mg/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 28,340,2014
In Vitro/nzxInhibitor Concentration (50 percent kill): 86.59 mg/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 28,340,2014
In Vitro/nzxInhibitor Concentration Low: 100 mg/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 28,340,2014
In Vitro/nzxInhibitor Concentration Low: 150 mg/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Apoptosis in vitro
TIVIEQ 28,340,2014
inhalation/rat lethal concentration (50 percent kill): 1440 mg/m3HBPTO* 2,1094,2001
inhalation/rat lethal concentration (50 percent kill): 1440 mg/m3/1H85GYAV -,70,1971
intramuscular/rat lethal dose (50 percent kill): 53 mg/kgBJIMAG 22,317,1965
intraperitoneal/hamster lethal dose (50 percent kill): 500 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 12 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAFCAU 16,561,1968
intraperitoneal/rat lethal dose (50 percent kill): 30 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
BWHOA6 44,241,1971
intravenous/rabbit lethal dose (50 percent kill): 5 mg/kgLung, Thorax, or Respiration: Other changesTXAPA9 165,27,2000
intravenous/rat lethal dose (50 percent kill): 11 mg/kgBJIMAG 22,317,1965
oral/chicken lethal dose (50 percent kill): 46500 µg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 7,606,1965
oral/Dog lowest published toxic dose: 5 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,697,2001
oral/Dog lowest published toxic dose: 2 mg/kgEye: Other eye effects

Gastrointestinal: Other changes

Skin and Appendages: Other: Sweating
HBPTO* 1,697,2001
oral/duck lethal dose (50 percent kill): 9580 µg/kgTXAPA9 22,556,1972
oral/guinea pig lethal dose (50 percent kill): 40 mg/kgHBPTO* 2,1094,2001
oral/human lowest published toxic dose: 0.36 mg/kgOlfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea
HBPTO* 1,697,2001
oral/human lowest published toxic dose: 0.36 mg/kgEye: Other eye effects

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1097,2001
oral/human lowest published toxic dose: 1.5 mg/kgBehavioral: Headache

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1097,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 90 mg/kgHPBIA9 21,53,1975
oral/mouse lethal dose (50 percent kill): 37 mg/kgHBPTO* 2,1094,2001
oral/mouse lethal dose (50 percent kill): 23500 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TOIZAG 17,60,1970
oral/pigeon lethal dose (50 percent kill): 7500 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 28 mg/kgTXAPA9 20,57,1971
oral/rabbit lowest published lethal dose: 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Somnolence (general depressed activity)
HBPTO* 1,697,2001
oral/rat lowest published toxic dose: 25 mg/kgBehavioral: Muscle contraction or spasticityHBPTO* 1,697,2001
oral/rat lethal dose (50 percent kill): 41 mg/kgYKYUA6 37,1621,1986
oral/rat lowest published toxic dose: 30 mg/kgBrain and Coverings: Recordings from specific areas of CNSNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 10 mg/kgNutritional and Gross Metabolic: Body temperature decreaseNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 3 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 29,87,2008
oral/rat lowest published toxic dose: 0.3 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 44,397,2005
oral/wild bird lethal dose (50 percent kill): 3800 µg/kgTXAPA9 21,315,1972
oral/woman lowest published lethal dose: 24 mg/kgBehavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Blood: Change in clotting factors
PGMJAO 63,311,1987
oral/woman lowest published lethal dose: 0.6 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Blood: Other hemolysis with or without anemia

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
JEMME* 34,295,2008
skin/mammal (species unspecified) lethal dose (50 percent kill): 800 mg/kgPSTDAN 15(10),37,1981
skin/mouse lethal dose (50 percent kill): >1360 mg/kgYKYUA6 31,711,1980
skin/rabbit lowest published toxic dose: 2000 mg/kgHBPTO* 1,697,2001
skin/rabbit lethal dose (50 percent kill): 500 mg/kgHBPTO* 2,1094,2001
skin/rabbit lowest published toxic dose: 2000 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
HBPTO* 1,697,2001
skin/rat lethal dose (50 percent kill): 800 mg/kgRPZHAW 22,579,1971
subcutaneous/mouse lethal dose (50 percent kill): 11400 µg/kgTOIZAG 17,60,1970
subcutaneous/mouse lowest published lethal dose: 22.2 mg/kgARTODN 76,173,2002
subcutaneous/rat lowest published toxic dose: 10 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TXAPA9 219,151,2007
subcutaneous/rat lethal dose (50 percent kill): 56 mg/kgYKYUA6 32,471,1981
Tank with water/Zebrafish Lowest published lethal concentration: 100 mg/L/24HReproductive: Other developmental abnormalitiesTIVIEQ 28,340,2014
Tank with water/Zebrafish Lowest published lethal concentration: 100 mg/L/48HReproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities
TIVIEQ 28,340,2014
Tank with water/Zebrafish lowest published toxic concentration: 100 mg/L/12HReproductive: Other developmental abnormalitiesTIVIEQ 28,340,2014
Tank with water/Zebrafish lethal concentration (50 percent kill): 166.4 mg/L/24HTIVIEQ 28,340,2014
Tank with water/Zebrafish lethal concentration (50 percent kill): 146.3 mg/L/48HTIVIEQ 28,340,2014
Tank with water/Zebrafish lethal concentration (50 percent kill): 134.8 mg/L/96HTIVIEQ 28,340,2014
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 100 mg/kgGISAAA 41(8),82,1976
unreported route/rat lethal dose (50 percent kill): 100 mg/kg30ZDA9 -,193,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 40 mg/kg/4W- intermittentImmunological Including Allergic: Increase in humoral responseINIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response
INIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 40 mg/kg/28D- intermittentImmunological Including Allergic: Increase in humoral response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
INIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg/28D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
INIMP* 4,1223,2004
oral/rabbit lowest published toxic dose: 534.36 mg/kg/1Y- intermittentKidney, Ureter, and Bladder: Interstitial nephritis

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 307,109,2013
oral/rat lowest published toxic dose: 255.3 mg/kg/6W- intermittentBehavioral: Change in psychophysiological tests

Liver: Changes in liver weight
EESADV 57,270,2004
oral/rat lowest published toxic dose: 85.1 mg/kg/2W- intermittentBehavioral: Alteration of classical conditioningEESADV 57,270,2004
oral/rat lowest published toxic dose: 864 mg/kg/13W- intermittentGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other
KHZDAN 22(6),584,1979
oral/rat lowest published toxic dose: 37500 µg/kg/50D- continuousBrain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thymus weight

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 27,465,1974
oral/rat lowest published toxic dose: 180 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
BECTA6 23,438,1979
oral/rat lowest published toxic dose: 1000 mg/kg/50D- continuousBehavioral: Change in psychophysiological testsHBPTO* 2,1100,2001
oral/rat lowest published toxic dose: 238.28 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count
TXCYAC 178,161,2002
oral/rat lowest published toxic dose: 238 mg/kg/4W- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight
TXCYAC 178,161,2002
oral/rat lowest published toxic dose: 714 mg/kg/12W- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight
TXCYAC 178,161,2002
subcutaneous/rat lowest published toxic dose: 70 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,151,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWNEJMAG 342,186,2000
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWNETOX* 26,573,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWNBREV* 9,479,1985
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTXCYAC 307,35,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWNETEEC 52,68,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,203,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 mg/m3;short term exposure limit 2 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPOXUR-air10H time-weighted average 0.5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1931; Number of Industries 15; Total Number of Facilities 2701; Number of Occupations 16; Total Number of Employees Exposed 27304; Total Number of Female Employees Exposed 4206
National Occupational Hazard Survey 1974Hazard Code M1931; Number of Industries 18; Total Number of Facilities 2519; Number of Occupations 14; Total Number of Employees Exposed 18098

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
On EPA IRIS database
Page last reviewed: November 16, 2018