NIOSH logo and tagline

Aniline

RTECS #
BW6650000
CAS #
62-53-3
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
93.14
Molecular Formula
C6H7N
Synonyms
Aminobenzene
Aminophen
Anilin (Czech)
Anilina (Italian, Polish)
Aniline and homologues (ACGIH:OSHA)
Aniline oil
Anyvim
Benzenamine
Benzene, amino
Benzidam
Blue Oil
C.I. 76000
C.I. Oxidation Base 1
Cyanol
Huile d'aniline (French)
Krystallin
Kyanol
NCI-C03736
Phenylamine
RCRA waste number U012

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,456,1986
skin /rabbit 20 mg/24H moderate85JCAE -,456,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat300 mg/kgMUREAV 79,173,1980
Cytogenetic Analysisovary/hamster444 mg/LEMMUEG 27,67,1996
Cytogenetic Analysisfibroblast/hamster1000000 µg/L (+enzymatic activation step)HPV371 -,-,2006
DNA adductoral/rat1397 mg/kg/30D-continuousTOXID9 -,345,2009
DNA Damageother cell types/rat1397.1 mg/kg/30D-continuousTOXID9 -,15,2008
DNA Damageoral/rat1397 mg/kg/30D- intermittentTXAPA9 233,247,2008
DNA Damageintraperitoneal/mouse300 mg/kgATSUDG 5,355,1982
DNA Damagelymphocyte/mouse21500 µmol/LMUREAV 203,155,1988
DNA Damageoral/mouse1 gm/kgMUREAV 440,1,1999
DNA Damageintraperitoneal/rat105 mg/kgCNREA8 42,2277,1982
DNA repair/Escherichia coli39658 µg/well/16HCBINA8 15,219,1976
micronucleus testintraperitoneal/mouse50 mg/kgJPMSAE 80,761,1991
micronucleus testunreported route/mouse23 mg/kgJAPTO* 25,514,2005
micronucleus testlung/hamster2500 µmol/L/6H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster5000 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster2500 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
morphological transformembryo/hamster485 mg/L/7DMUREAV 755,108,2013
morphological transformfibroblast/mouse0.01 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
morphological transformfibroblast/mouse800 µg/LJJIND8 67,1303,1981
mutation in mammalian somatic cellslymphocyte/mouse2500 µmol/LMUTAEX 3,193,1988
mutation in mammalian somatic cellslung/hamster500 µg/LBLFSBY 39,359,1986
mutation in microorganisms/Salmonella typhimurium344 nmol/plate/48H (+enzymatic activation step)MUREAV 541,123,2003
mutation in microorganisms/Salmonella typhimurium1 µg/plateMUREAV 577S,1,2005
mutation in microorganismslymphocyte/mouse500 µmol/L (+enzymatic activation step)MUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)PJABDW 53,34,1977
sister chromatid exchangelymphocyte/human300 µmol/LMUREAV 395,159,1997
sister chromatid exchangeliver/rat200 µmol/LTOLED5 16,235,1983
sister chromatid exchangeovary/hamster50 mg/LEMMUEG 10(Suppl 10),1,1987
sister chromatid exchangeintraperitoneal/mouse210 mg/kgCNREA8 42,2277,1982
specific locus testlymphocyte/mouse500 mg/LEMMUEG 17,196,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 4480 mg/kg (6-13D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TCMUD8 7,29,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 11 gm/kg/29W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
APMIAL 26,472,1949
oral/rat toxic dose: 72800 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
FCTOD7 25,619,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 930.0 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, leukemia cells Inhibitor Concentration (50 percent kill): 927.9 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,1150,2012
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 59 gm/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 55 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 64 gm/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 4.7 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 4.5 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lymphocyte Inhibitor Concentration (30 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (50 percent kill): 63 mg/L/45HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,901,2015
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 2300 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 199,51,2010
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 2.3 mmol/L/2HIn Vitro Toxicity Studies: Other assaysTOLED5 199,51,2010
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.9 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.4 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 1226 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 1430 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 1226 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 920 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): 3072 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): 2700 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): 2793 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): 4003 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 40.7 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 102.3 mmol/L/1HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 70.8 mmol/L/1HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 28.8 mmol/L/1HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIVIEQ 32,347,2016
inhalation/cat Lowest published lethal concentration: 180 ppm/8HXPHBAO 271,4,1941
inhalation/Dog lowest published toxic concentration: 23.6 mg/m3Blood: Methemoglobinemia- CarboxhemoglobinemiaTXCYAC 214,140,2005
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 2500 mg/m3GTPZAB 32(10),25,1988
inhalation/mouse lethal concentration (50 percent kill): 175 ppm/7HNTIS** PB214-270
inhalation/rat Lowest published lethal concentration: 250 ppm/4HJIHTAB 31,343,1949
inhalation/rat lethal concentration (50 percent kill): 250 ppm/1HENTOX* -,136,2005
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
TPKVAL 12,54,1971
inhalation/rat lowest published toxic concentration: 0.09 gm/m3/4HBehavioral: Alteration of classical conditioning

Vascular: Other changes

Gastrointestinal: Ulceration or bleeding from stomach
TPKVAL 12,54,1971
inhalation/rat lowest published toxic concentration: 0.006 gm/m3/4HTPKVAL 12,54,1971
intraperitoneal/guinea pig lethal dose (50 percent kill): 100 mg/kgTSCAT* OTS 206512
intraperitoneal/mouse lethal dose (50 percent kill): 368 mg/kgHPV300 -,-,2001
intraperitoneal/rat lethal dose (50 percent kill): 420 mg/kgAGGHAR 15,447,1957
intravenous/Dog lowest published lethal dose: 200 mg/kgNTIS** PB214-270
intravenous/rabbit lethal dose (50 percent kill): 64 mg/kgNTIS** PB214-270
oral/cat lowest published lethal dose: 100 mg/kgHBAMAK 4,1301,1935
oral/child lowest published toxic dose: 3125 mg/kgLung, Thorax, or Respiration: CyanosisJTCTDW 26,357,1988
oral/Dog lethal dose (50 percent kill): 195 mg/kgNTIS** PB214-270
oral/guinea pig lethal dose (50 percent kill): 400 mg/kgTSCAT* OTS 206512
oral/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 464 mg/kgENTOX* -,136,2005
oral/quail lethal dose (50 percent kill): 750 mg/kgAECTCV 12,355,1983
oral/rabbit lowest published lethal dose: 500 mg/kgHBAMAK 4,1301,1935
oral/rat lethal dose (50 percent kill): 250 mg/kgJPETAB 90,260,1947
oral/rat lowest published toxic dose: 1118 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTPKVAL 14,118,1975
oral/rat lowest published toxic dose: 1000 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Spinal Cord: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOPADD 14,19,2001
oral/rat lowest published toxic dose: 1000 mg/kgSpinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TOXID9 12,470,2008
oral/wild bird lethal dose (50 percent kill): 562 mg/kgAECTCV 12,355,1983
skin/cat lethal dose (50 percent kill): 254 mg/kgGTPZAB 13(5),29,1969
skin/Dog lowest published lethal dose: 1540 mg/kgNTIS** PB214-270
skin/guinea pig lethal dose (50 percent kill): 1290 mg/kgTXAPA9 7,559,1965
skin/rabbit lethal dose (50 percent kill): 820 µL/kgTXAPA9 7,559,1965
skin/rat lethal dose (50 percent kill): 1400 mg/kgENTOX* -,136,2005
subcutaneous/cat lowest published lethal dose: 100 mg/kgHBAMAK 4,1301,1935
subcutaneous/mouse lethal dose (50 percent kill): 200 mg/kgARZNAD 8,107,1958
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgLung, Thorax, or Respiration: Other changesMELAAD 28,112,1937
unreported route/man lowest published lethal dose: 350 mg/kgJIDHAN 13,87,1931
unreported route/man lowest published lethal dose: 150 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 3 mg/m3/22W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
GISAAA 37(5),31,1972
inhalation/rat lowest published toxic concentration: 87 ppm/6H/2W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
TOXID9 2,164,1982
inhalation/rat lowest published toxic concentration: 300 µg/m3/24H/80D- continuousBehavioral: Muscle contraction or spasticityGISAAA 35(4),44,1970
inhalation/rat lowest published toxic concentration: 5 mg/m3/24H/21D- continuousBlood: Methemoglobinemia- CarboxhemoglobinemiaGISAAA 37(12),53,1972
inhalation/rat lowest published toxic concentration: 30 ppm/14D- continuousBlood: Other hemolysis with or without anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen
HPV371 -,,2006
inhalation/rat lowest published toxic concentration: 45 ppm/6H/27D- intermittentBlood: Normocytic anemiaTOLED5 255,11,2016
intraperitoneal/mouse lowest published toxic dose: 894 mg/kg/6W- intermittentImmunological Including Allergic: Autoimmune (multiple organ involvement)TOXID9 44,187,2005
oral/rat lowest published toxic dose: 1397.1 mg/kg/30D- continuousBlood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 -,22,2008
oral/rat lowest published toxic dose: 651.98 mg/kg/7D- intermittentBlood: Changes in spleenTXAPA9 230,227,2008
oral/rat lowest published toxic dose: 1397 mg/kg/30D- continuousBlood: Changes in spleenTOXID9 -,345,2009
oral/rat lowest published toxic dose: 2200 mg/kg/20D- continuousEndocrine: Changes in spleen weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV371 -,,2006
oral/rat lowest published toxic dose: 2800 mg/kg/28D- intermittentBlood: Normocytic anemiaTOLED5 255,11,2016
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentBehavioral: Food intake (animal)TOLED5 255,11,2016
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 255,11,2016
oral/rat lowest published toxic dose: 913 mg/kg/2W- intermittentEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FAATDF 25,224,1995
oral/rat lowest published toxic dose: 550 mg/kg/5D- continuousBlood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 3,285,1983
oral/rat lowest published toxic dose: 210 mg/kg/12W- continuousBlood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
GISAAA 24(7),44,1959
subcutaneous/rat lowest published toxic dose: 900 mg/kg/6D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
BCTKAG 13,99,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,99,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 4,27,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,99,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,99,1987
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWTOLED5 140-141,229,2003
TOXICOLOGY REVIEWTOLED5 140-141,183,2003
TOXICOLOGY REVIEWTXAPA9 197,144,2004
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,136,2005
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 627,78,2007
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 752,99,2013
TOXICOLOGY REVIEWMUREAV 770,170,2016
TOXICOLOGY REVIEWRTOPDW 54,247,2009
TOXICOLOGY REVIEWRTOPDW 55,43,2009
TOXICOLOGY REVIEWRTOPDW 55,52,2009
TOXICOLOGY REVIEWRTOPDW 56,54,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (19 mg/m3)DTLVS* 3,13,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 2 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (7.6 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (8 mg/m3);KZW 10 ppm (40 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (7.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (4 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (7.7 mg/m3), short term exposure limit 4 ppm (15 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (10 mg/m3), Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (7.7 mg/m3), skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 8 mg/m3, short term exposure limit 32 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (4 mg/m3), skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (3.8 mg/m3), skin, s1 sen(pr), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (10 mg/m3);short term exposure limit 5 ppm (20 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (4 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (7.6 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 20 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (4 mg/m3);short term exposure limit 2 ppm (8 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (8 mg/m3), KZG-week 4 ppm (16 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (4 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (19 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (19 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (19 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (19 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANILINE AND HOMOLOGS-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 06580; Number of Industries 21; Total Number of Facilities 748; Number of Occupations 39; Total Number of Employees Exposed 41988; Total Number of Female Employees Exposed 14949
National Occupational Hazard Survey 1974Hazard Code 06580; Number of Industries 25; Total Number of Facilities 1868; Number of Occupations 46; Total Number of Employees Exposed 21859

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; E coli polA with S9
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002
On EPA IRIS database
Page last reviewed: November 16, 2018