Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, October 29, 2009       Volume 23   Number 18

 

Spotlight

NIH Announces New Comparative Effectiveness Research Projects in Genomics and Personalized Medicine

This month NIH’s National Cancer Institute announces seven new projects comparing and evaluating the clinical validity and utility and cost-effectiveness of genomic and personalized medicine applications to existing standards of care and prevention for cancer. These projects will become part of the new CDC initiative called Genomic Applications in Practice and Prevention Network (GAPPNet). Learn more about the funded projects. Learn about public health genomics at NCI.

 

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Announcements

• New publication, Phenopedia and Genopedia: Disease-centered and Gene-centered Views of the Evolving Knowledge of Human Genetic Associations , published ahead of print on October 27, 2009 in the Advance Access version of Bioinformatics. Authors: Yu W, Clyne M, Khoury MJ, and Gwinn M.
• Podcast now available of the Personalized Genomics: Hope or Hype? The 2009 Michael Smith Memorial Nobel Forum held on March 11, 2009, in British Columbia, featuring Muin J. Khoury, Cynthia Kenyon, and Nobel Laureate Harold Varmus. Listen to the podcast [audio MP3 - 53:35 min.] .
• New Healthy People 2020 objectives now posted, including new genomics-related objectives. Public comment will open on October 30, 2009.
• The Emory University/Georgia Institute of Technology Predictive Health Institute will sponsor its 5th Predictive Health Symposium on December 14-15, 2009 in Atlanta, GA. View the agenda. Register now.
• Oregon’s Department of Health has released 2008 Behavioral Risk Factor Surveillance System (BRFSS) data on family history and colorectal cancer [PDF 58.37 KB]. Visit the Web page to access data for other years.
• October is breast and ovarian cancer month. Learn more about: the role of family health history and risk categories, genetic testing information and guidelines, and genetic counseling.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Northwestern University to establish research center for the study of genes and their role in cancer, News-Medical.Net, October 27

Cancer genomics in the spotlight at ASHG, Genome Web, October 26 [by free subscription only]

A novel gene-silencing protein offers new possibilities for treatment of cancer and genetic disorders, Medical News Today, October 26

Cardiovascular Disease

Families with 'genes of death' can be identified and helped at new Montefiore-Einstein center for cardiogenetics, Medical News Today, October 27

Ethical, Legal, and Social Issues (ELSI)

New standards for genome sequence data quality, PHG Foundation, October 27

Family History

Family history can hint at how the future will shape up, The Washington Post, October 27

Genes and Environment

Examining genetic variations among the Huichol population of Mexico, Medical News Today, October 27

A polymorphism of the µ-opioid receptor is linked to alcohol misuse among adolescents, EurekAlert, October 26

Gene Therapy

Injured human donor lungs repaired by gene therapy, Medical News Today, October 29

Gene therapy restores sight to children with congenital blindness, Medical News Today, October 28

Genetic Testing

Genetic testing soon to screen for breast cancer, Khaleej Times Online, October 29

Genetic screening for mitchondrial diseases, PHG Foundation, October 28

New tests hope to better identify breast cancer risk, NBC DFW, October 28

Report focusing on health-related decision-making applications of DTC genetic tests in the U.S., News-Medical.Net, October 27

National survey by American Medical Association and Medco shows physicians see value in genetic testing; cite need for greater education to put it into practice, South Florida Business Journal, October 23

Quick and easy diagnosis for mitochondrial disorders, EurekAlert, October 22

Infectious Disease

Genomics can provide insights in understanding emerging infectious disease, New-Medical.Net, October 27

Mental Health

Susceptibility to schizophrenia and autism may have common genetic fingerprints, says researchers, News-Medical.Net, October 28

'Culture of we' buffers genetic tendency to depression, EurekAlert, October 27

Pharmacogenomics

The best medications for your genes, Forbes, October 27

Other News

International access to diagnostic mutation database, PHG Foundation, October 22

News Note: Comparative effectiveness grants in genomic and personalized medicine announced, Medical News Today, October 22

Scientists discover gene key to human speech, Yahoo News, October 22

Some parts of human genome get lost, Medline Plus, October 22

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Genomics in the Scientific Literature

 

Autoimmune Disease

Genetics of rheumatic disease
Clarke A & Vyse TJ
Arthritis Res Ther 2009 Oct;11(5):248

An overview of genetics of paediatric rheumatic diseases
Woo P & Colbert RA
Best Pract Res Clin Rheumatol 2009 Oct;23(5):589-97

Cancer

Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Colorectal Cancer: A HuGE-GSEC Review
Taioli E, et al.
Am J Epidemiol 2009 Oct

Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism
Seitz HK & Stickel F
Genes Nutr 2009 Oct

Identification of Non-Hodgkin's Lymphoma Prognosis Signatures Using the CTGDR Method
Ma S, et al.
Bioinformatics 2009 Oct

Cardiovascular Disease

The Role of Vascular Endothelial Growth Factor Gene as the Genetic Marker of Atherothrombotic Disorders and in the Gene Therapy of Coronary Artery Disease
Petrovic D
Cardiovasc Hematol Agents Med Chem 2009 Oct

Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository
Koontz JI, et al.
Am Heart J 2009 Nov;158(5):719-25

Detecting rare variants for complex traits using family and unrelated data
Zhu X, et al.
Genet Epidemiol 2009 Oct

Epigenomics

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
Lahiri DK, et al.
Mol Psychiatry 2009 Nov;14(11):992-1003

Genome-scale approaches to the epigenetics of common human disease
Feinberg AP
Virchows Arch 2009 Oct

Family History

Elevated Cancer Mortality in the Relatives of Patients with Pancreatic Cancer
Wang L, et al.
Cancer Epidemiol Biomarkers Prev 2009 Oct

Primary Care Providers' Responses to Patient-Generated Family History
Fuller M, et al.
J Genet Couns 2009 Oct

Genetic Testing

Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer?
Soares P & Sobrinho-Simoes M
Future Oncol 2009 Oct;5(8):1225-9

Maternal and Child Health

Genetic, environmental, and epigenetic factors in the development of personality  disturbance
Depue RA
Dev Psychopathol 2009 Fall;21(4):1031-63

The genetics of attention-deficit/hyperactivity disorder
Coghill D & Banaschewski T
Expert Rev Neurother 2009 Oct;9(10):1547-65

Newborn Screening

Utilization of Blood Spot Testing for Metabolic-Genetic Disorders in Honduras: Is it Time for Newborn Screening?
Slaughter JL, et al.
J Child Neurol 2009 Oct

Pharmacogenomics

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder
Garriock HA, et al.
Biol Psychiatry 2009 Oct

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of  anticoagulant therapy (EU-PACT) trial design
van Schie RM, et al.
Pharmacogenomics 2009 Oct;10(10):1687-95

How will GINA influence participation in pharmacogenomics research and clinical testing?
Dressler LG & Terry SF
Clin Pharmacol Ther 2009 Nov;86(5):472-5

Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches
Ikeda M, et al.
Biol Psychiatry 2009 Oct

Mitochondrial gene profiling: translational perspectives
Johnston DS, et al.
Pharmacogenomics 2009 Oct;10(10):1645-55

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology
McDermott U & Settleman J
J Clin Oncol 2009 Oct

Pharmacogenetics and pharmacogenomics of sexual dysfunction: current status, gaps and potential applications
Abdel-Hamid IA & Andersson KE
Pharmacogenomics 2009 Oct;10(10):1625-44

Pharmacogenetics of tenofovir treatment
Rodriguez-Novoa S, et al.
Pharmacogenomics 2009 Oct;10(10):1675-85

Obesity

Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene
Johansson A, et al.
Obesity (Silver Spring) 2009 Oct

Other

Common disorders are quantitative traits
Plomin R, et al.
Nat Rev Genet 2009 Oct

Ecuador: Public Health Genomics
Gonzalez-Andrade F & Lopez-Pulles R
Public Health Genomics2009 Oct

Nursing advocacy in a postgenomic age
Hamilton R
Nurs Clin North Am 2009 Dec;44(4):435-46

Meta-analysis of genome-wide association studies: no efficiency gain in using individual participant data
Lin DY & Zeng D
Genet Epidemiol 2009 Oct

Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse
Nakaoka H & Inoue I
J Hum Genet 2009 Oct

Genetics of food allergy
Hong X, et al.
Curr Opin Pediatr 2009 Oct

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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