Genomics Translation
Genomics Translation Projects Supported by AHRQ
Evidence evaluation for clinical guidelines/recommendations
Evidence evaluation for other stakeholders
Creating new evidence
Knowledge dissemination
Implementation into clinical practice
Methods and conceptual frameworks
Evidence evaluation for clinical guidelines/recommendations:
- BRCA mutation testing - U.S. Preventive Services Task Force
- Screening for hemochromatosis - U.S. Preventive Services Task Force
- CYP450 testing in depression - Evaluation of Genomic Applications in Practice and Prevention
- Gene expression profiling (GEP) tests in breast cancer - Evaluation of Genomic Applications in Practice and Prevention
- HNPCC testing in colorectal cancer - Evaluation of Genomic Applications in Practice and Prevention
- Factor V/Prothrombin mutation testing - Evaluation of Genomic Applications in Practice and Prevention
Evidence evaluation for other stakeholders:
- Genomic testing in ovarian cancer - CDC
- Horizon scan on use of genetic testing in cancer - CMS
- Horizon scan on genetic tests in non-cancer diseases – CMS
- Selected pharmacogenetic tests in cancer and other diseases – CMS
- BNP testing in heart failure – AACC, ACP, ACEP, ACCP
- HER2/Neu testing in breast and other solid tumors – AACC
- Cancer family history – CDC
- Cancer family history: collection and use
- Cancer family history: clinical utility
- Family history in primary care – NIH (state of science conference)
Creating new evidence:
- Infrastructure for monitoring utilization and outcomes of gene-based clinical applications: an assessment – CDC
- Cost-effectiveness of DNA stool testing in colorectal cancer – CMS
- Comparison of gene-based to non-gene-based dosing on outcomes of warfarin therapy
- Role of OCT genetic variations in metformin effectiveness – NIH co-funding
- Pharmacogenetic evaluation of QTc prolongation in women entering a methadone maintenance treatment program
- Clinical and economic implications of genetic testing for warfarin management
- Pharmacogenetics of mycophenolate mofetil (MMF) in recipients of pediatric kidney
- Pharmacogenetics to optimize dosing of psychostimulants in children with attention deficit hyperactivity disorder (ADHD)
Knowledge dissemination:
Implementation into clinical practice:
Methods and conceptual frameworks:
- Analytic validity, quality rating and evaluation frameworks for genetic and other laboratory tests
- Genetic testing – draft chapter in methods guide for comparative effectiveness reviews
- DARTNet (distributed ambulatory research in therapeutics network): a new electronic infrastructure for conducting comparative effectiveness studies in EMR-enabled clinics in primary practice
- HMORN distributed research project
Contact Us:
- CDC-INFO Contact Center
Phone: 800-232-4636 (800-CDC-INFO)
Hearing Impaired: 888-232-6348 - cdcinfo@cdc.gov
- Additional information for Public Health Genomics is available on our contact page.
