Concurrent Administration of Influenza Vaccine With Other Vaccines

Limited data are available on the concurrent administration of influenza vaccines with other live vaccines. Use of LAIV3 concurrently with measles, mumps, rubella (MMR) and varicella vaccine among children aged 12 through 15 months has been studied, and no interference with the immunogenicity to antigens in any of the vaccines was observed (449). Among adults aged ≥50 years, the safety and immunogenicity of zoster vaccine and IIV3 were similar whether administered simultaneously or sequentially spaced 4 weeks apart (450).

In the absence of specific data indicating interference, following ACIP’s general recommendations for vaccination is prudent (8). Inactivated vaccines do not interfere with the immune response to other inactivated vaccines or to live vaccines. LAIV4 is not recommended for use in 2016–17. Providers considering its use should note that although inactivated or live vaccines can be administered simultaneously with LAIV4, after administration of a live vaccine (such as LAIV4), at least 4 weeks should pass before another live vaccine is administered.