Influenza Vaccines and Use of Influenza Antiviral Medications

Administration of IIV to persons receiving influenza antiviral drugs for treatment or chemoprophylaxis is acceptable. ACIP recommends that LAIV4 should not be used during the 2016–17 season. However, if used, LAIV4 should not be administered until 48 hours after cessation of influenza antiviral therapy, because antiviral drugs reduce replication of influenza viruses (444). If influenza antiviral medications are administered within 2 weeks after receipt of LAIV4, the LAIV4 dose should be repeated ≥48 hours after the last dose of antiviral medication. Alternatively, persons receiving antiviral drugs within the period 2 days before to 14 days after vaccination with LAIV4 may be revaccinated with another appropriate vaccine formulation (e.g., IIV or RIV).